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Solubility: DMSO: ≥ 31 mg/mL
and is ATP competitive with a Ki value of 0
MGCD0103 also exhibits dose-dependent inhibition of HDAC activity in whole cells
Chekler EL
While nM concentrations of U0126 are efficient to reduce H1N1v and H5N1 (MB1)
OSI-027 - mTOR Inhibitor. CAS# 936890-98-1 Catalog No.:M60113-10S Solubility: DMSO: ≥ 31 mg/mLOSI 027, CAS No. 936890 98 1, is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. It shows more than 100 fold selectivity for mTOR relative to PI3K, PI3K, PI3K, and DNA PK. It inhibits phosphorylation of the mTORC1 substrates 4E BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo. OSI 027 shows robust antitumor activity in several different human xenograft
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